Celule susa hematopoietice, descoperite in tesutul adipos
Tesutul adipos contine un numar foarte mare de celule susa hematopoietice, asemanatoare cu cele din maduva osoasa, capabile sa se diferentieze in celule imunitare, arata concluziile unui studiu realizat pe soareci si publicat de revista americana Stem Cell jogos casino online.
Rezultatele nu au fost confirmate pe subiecti umani, insa daca se va demonstra ca tesutul adipos uman contine celule hematopoietice capabile sa se diferentieze in mastocite (celule imunitare) sau alte tipuri de celule, va fi revolutionat domeniul hematopoiezei, sustine coautoarea studiului, Beatrice Cousin, de la Centre National de la Recherche Scientifique Bonus Fara Depunere
Pana acum, celulele sangvine erau produse doar de celulele susa din maduva osoasa. Prelevarea acesteia este "complicata si foarte invaziva", in timp ce tesutul adipos exista in cantitati mari ai este usor de extras. Potrivit studiilor anterioare, tesutul adipos, compus in mare parte din celule incarcate cu lipide (adipocite), adaposteste si anumite tipuri de celule prezente in sange. Oamenii de stiinta au crezut, insa, multa vreme, ca acestea provin din maduva osoasa.
Cercetătorii au reusit sa izoleze, la nivelul tesutului adipos al soarecilor, o populatie de celule susa hematopoietice capabile sa genereze mastocite, implicate in procesele inflamatorii si alergice. Pentru a determina rolul lor, oamenii de stiinta au reinjectat aceste celule susa hematopoietice in sistemul circulator al soarecilor, la concurenta cu cele produse in maduva osoasa. S-a constatat ca mastocitele din intestin si din piele proveneau in principal din celulele susa hematopoietice prezente in tesuturile adipoase.
S-a constatat astfel ca celulele susa sunt capabile sa colonizeze si alte tipuri de tesuturi, in afara de maduva osoasa si sa se diferentieze in mastocite functionale. Mastocitele sunt omniprezente in sistemul imunitar, devenind foarte active atunci cand apare o inflamatie cauzata de un virus sau de o bacterie.
Daca celulele susa hematopietice vor fi descoperite si la oameni, se vor deschide perspective terapeutice majore pentru tratarea unor maladii imunitare precum obezitatea, diabetul, ateroscleroza, osteoartrita si chiar alergiile", au explicat cercetatorii CNRS si ai Universitatii Paul Sabatier din Toulouse.
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