Adenoamele pituitare sporadice si MEN1
Tratamentul tumorilor pituitare depinde de prezentarea lor clinica. Obiectivele urmarite de instaurarea tratamentului sunt acelea de a reduce volumul tumorii si/sau hipersecretia hormonala.
Alegerea terapeutica (chirurgicala, radioterapia, medicala) depinde de agresivitatea tumorii. In unele adenoame pituitare sunt identificate mutatii ale genei MEN1 (neoplazia endocrina multipla tip 1).
Gena MEN 1 este o gena "tumour suppressor", localizata pe cromozomul 11q13 si care codifica menina, o proteina constituita din 610 aminoacizi. Adenoamele asociate cu prezenta MEN1 sunt mai agresive si mai putin sensibile la tratament in comparatie cu adenoamele pituitare sporadice. (Beckers A. et al, J Intern Med 2003)
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