Incidenta mare de evenimente cardiovasculare este asociata coronaropatiei
Scleroza aortica este asociata cu un outcome cardiovascular nefavorabil. Cercetatorii de la Beaumont Hospital del Royal Oak (SUA) au evaluat existenta unei relatii dintre scleroza aortica, markerii serici si outcome-ul cardiovascular nefavorabil.
Studiul a fost facut pe un lot de 425 pacienti, varsta medie 68 ani, ajunsi la Camera de Urgenta cu durere toracica, scleroza aortica fiind identificata la 203 subiecti (49%).
La un an de la inceputul monitorizarii lor, pacientii cu scleroza aortica aveau o incidenta majora de evenimente cardiovasculare si de mortalitate, in comparatie cu grupa ai carei pacienti prezentau o afectiune valvulara (16,8%
versus 7,1%; p = 0,002).
Totusi, in analize complexe, scleroza nu a fost asociata in mod independent outcome-ului cardiovascular nefavorabil. Singurii predictori independenti de
mortalitate sau infarct miocardic, dupa un an, erau afectiunea cardiaca (raport de risc, HR: 3,23), nivele mari de CRP (HR: 2,2) si influenta cardiaca congestiva (HR = 2,15).
Din acest studiu se distinge faptul ca ca dimensiunea incidentei evenimentelor cardiovasculare la pacientii cu scleroza aortica nu depinde de afectiunea valvulara in sine, ci de afectiunea coronariana si de inflamatie. (Chandra Hr. et al, J Am Coll Cardiol 2004)
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