Interferonul gamma-1b nu influenteaza evolutia fibrozei pulmonare idiopatice

Interferonul gamma-1b nu a demonstrat beneficii semnificative la pacientii cu fibroza pulmonara idiopatica si care nu raspundeau la tratamentul cu corticoizi. Cercetatorii Idiopathic Pulmonary Fibrosis Study au evaluat eficacitatea Interferonului gama-1b la acesti pacienti.

Pentru aceasta au fost supravegheati 330 pacienti cu fibroza pulmonara idiopatica, carora li s-a administrat in mod random interferon gama-1b sau placebo. Terapia cu interferon nu a influentat progresia bolii.

Pe langa aceasta nu a fost observata nici un efect semnificativ asupra functiunii pulmonare sau asupra calitatii vietii. Circa 10% dintre pacientii tratati cu interferon gama-1b au decedat fata de un procent de 17% dintre pacientii grupului "placebo".

Tot printre pacientii tratati cu interferon au fost observate cazuri de pneumonie, dar la ambele grupe s-a inregistrat aceeasi incidenta de grave
infectii ale tractului respirator. (Raghu G. et al, N Engl J Med 2004)

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