Intoleranta la paroxetina are baze genetice
Cercetatorii Standford University School of Medicine au evaluat daca variatiile secventelor codificante pentru citocromului P450 (CYP2D6) sau pentru receptorul de serotonina 5-HT-2A pot sta la baza intolerantei la paroxetina.
Pacientilor in varsta (65 de ani si mai mult) li s-a administrat randomizat paroxetina si mirtazapina, un antidepresiv NaSSA. 46,3% dintre pacienti cu
genotipul C/C al receptorului de serotonina au fost nevoiti sa intrerupa tratamentul cu paroxetina din cauza efectelor indezirabile. (Murphy G.M. et al, Am J Psychiatry 2003)
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