Nivelele plasmatice de aldosteron si progresia insuficientei cardiace
Aldosteronul a fost socotit a avea un rol in progresia insuficientei cardiace. Analiza datelor studiului Val-HeFT (Valsartan Heart Failure Trial) a cautat sa verifice aceasta ipoteza. Au fost masurate nivelele plasmatice ale aldosteronului pe toata durata de observatie, ale pacientilor tratati
cu Valsartan (dozaj de 160 mg de doua ori pe zi) sau placebo.
La finele studiului nivelele de aldosteron au crescut in medie de 17,8 +/- 3 pg/mL (+11,9%) la grupul placebo, in timp ce la grupul Valsartan acestea s-au diminuat de 23,8 +/-3 pg/mL (-17,4%). Efectul acestui medicament a dat rezultate asemanatoare la toate subgrupele de pacienti, chiar si la acei carora li se administra ACE-inhibitori sau betablocante.
Reducerea similara a morbiditatii si mortalitatii in toate subgrupele a reliefat ca nivelele plasmatice ale aldosteronului pot sa nu reprezinte un
marker important pentru progresia insuficientei cardiace. (Cohn J.N. et al, Circulation 2003)
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