Administrarea intracoronariana de Ad5FGF-4 la pacientii cu angina stabila

Obiectivul studiului condus de cercetatorii implicati in desfasurarea studiului AGENT-2 Study, a fost acela de verificare daca administrarea de gene codificante pentru factorul de crestere a fibroblastelor (Ad5FGF-4) poate fi in masura de a reducere perfuzia miocardica in comparatie cu placebo.

Un total de 52 de pacienti cu angina stabila si ischemie reversibila au primit randomizat terapie genica sau placebo, iar dupa opt saptamani au fost supusi tomoscintigrafiei jogos casino online.

Administrarea de Ad5FGF-4 a produs o reducere semnificativa a dimensiunii ariei ischemice comparativ cu pacientii tratati placebo, unde nu s-a inregistrat nici o ameliorare.

Ad5FGF-4 a fost bine tolerat fara nici un efect secundar permanent, autorii studiului concluzionand ca infuzia intracoronariana de Ad5FGF-4 a redus necesitatea perfuziei miocardice. (Grines C.L. et al, J Am Coll Cardiol 2003)

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