Hepatita fulminanta indusa de virusul VSH: rolul apoptozei in leziunile hepatice
Hepatita fulminanta indusa de virus herpes simplex este foarte rara. Scopul studiului, care a avut acest subiect, a fost acela de a stabili rolul apoptozei, cunoscuta si ca moarte celulara programata, in hepatita fulminanta de HSV.
Au fost analizate mostre de ficat afectat de hepatita herpetica fulminanta si mostre de ficat infectat cu virusul hepatitei B si Rickettsia. S-a observat o crestere a numarului de celule, la experimentele cu caspaza-3 pozitiva, in
cazurile de hepatita fulminanta de HSV, respectiv la ficatul infectat, in stare cronica, cu hepatita B sau cu hepatita acuta Rickettsia.
Aceste date au demonstrat ca apoptoza e responsabila, macar partial, de leziunile hepatice aparute in timpul hepatitei fulminante de HSV. (Pretet J.L. et al, Apoptosis. 2003)
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